Share

Stanford achieves COMPLETE memory restoration in AD models by blocking metabolic switch + 75% patients have hidden sleep apnea (and it's consequences!)

Wednesday plenary from the AAIC, fresh from July 2025.

5 min read
Stanford achieves COMPLETE memory restoration in AD models by blocking metabolic switch + 75% patients have hidden sleep apnea (and it's consequences!)
Evidence-Backed

Stanford achieves COMPLETE memory restoration in AD models by blocking metabolic switch + 75% patients have hidden sleep apnea (and it's consequences!)

Wednesday plenary from the AAIC, fresh from July 2025.

As always these conference are the opportunity for researchers to present their latest findings, often not yet published. So if you are curious about the cutting edge science, tune in!

Two separate research teams just revealed findings that could give us great insights about how we prevent Alzheimer's.

  1. Dr. Andreasson from Stanford discovered neurons aren't dying in AD - they're STARVING. An enzyme called IDO1 hijacks the brain's energy supply. When her team blocked it? Complete memory restoration. Not improvement. RESTORATION.

  2. Professor Naismith from Sydney revealed that 75% of memory clinic patients have sleep apnea they don't know about. Every night, their brains are being damaged by oxygen deprivation. One bad night = 2 days of impaired toxic protein clearance.

The kicker? We already have treatments:

- IDO1 inhibitors passed safety trials

- CPAP protects against cognitive decline  

- DORAs improve sleep AND reduce tau

Neither study looked at APOE4 carriers specifically (we need to advocate for this!), but these are fundamental brain mechanisms that likely affect all of us.

I break down everything in detail here:

Questions for discussion:

- Have you had a sleep study? (75% chance you need one!)

- Are you tracking your sleep quality?

- What's holding you back from getting evaluated?Sharon L. Naismith (Charles Perkins Centre — University of Sydney, Australia) - Waking Up to the Importance of Sleep in MCI and AD

Katrin Andreasson (Stanford University, CA, USA) - Restoring Hippocampal Glucose Metabolism Rescues Cognition Across Alzheimer’s Disease Pathologies

Free Weekly Newsletter

Get Weekly Protocols

Join + readers getting evidence-based APOE4 strategies.

Weekly protocols
Research updates
No spam
Written by

Phoenix Team

Phoenix Team is a contributor to the APOE4 Blog, sharing evidence-based insights for the APOE4 community.

More from Phoenix
Keep Reading

Related Articles

More about Sleep