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The Best Omega-3 supplement for APOE4 Carriers

I've been taking LPC-DHA since day one. It's not cheap...but $3/day is nothing compared to the alternative...

6 min read
The Best Omega-3 supplement for APOE4 Carriers
Evidence-Backed

The Best Omega-3 supplement for APOE4 Carriers

I've been taking LPC-DHA since day one. It's not cheap...but $3/day is nothing compared to the alternative...

I've been taking LPC-DHA since the day I discovered my APOE4 status.

It's not a cheap product. Almost $3 a day for a single supplement.
And the annoying part? You can never directly measure if it's working. There's no blood test that tells you "yes, your brain DHA is now optimal."

But here's how I think about it: $3 a day is a very small price to pay if the alternative is Alzheimer's down the line.

So I've always bitten the bullet.

To my knowledge, there are only two providers of LPC-DHA in the world, as it is a patented product:

  • LPC Neuro — covers Asia (what I was taking when I lived in Singapore)

  • Accentrate Omega Max — covers the US, Canada, UK, Australia, New Zealand

Last month, I published two deep dives on why LPC-DHA matters for us—and why standard fish oil falls short.

Since then, my inbox has been flooded by members with the same question:
"Kevin, is there a discount code for LPC-DHA?"

I'm glad to say we made it happen.

Here’s the link to buy Accentrate Omega Max which I have been taking for the past 5 months. To get 20% off for Phoenix Members use code: PHOENIX

Why LPC-DHA? (Quick Science Recap)

The short version: our impaired lipid transport means regular DHA often never reaches our brains. You might have a perfect omega-3 index, but that's a blood biomarker—a poor proxy for whether DHA is actually getting to your brain, which is where it matters.

LPC-DHA uses a different pathway (the Mfsd2a transporter) that bypasses our broken system.

1. Standard fish oil has limited brain entry

DHA from triglycerides (standard fish oil) gets incorporated into fat tissue and heart—but not brain. LPC-DHA increased brain DHA by up to 100%. Over 80% of dietary DHA from fish oil is oxidized before reaching the brain.

2. LPC-DHA bypasses our impaired transport

The brain has a transporter called Mfsd2a at the blood-brain barrier. It doesn't transport regular DHA—only LPC-DHA. A 2017 study showed LPC-DHA increased brain DHA by more than 2-fold. Free DHA? No effect. Mice on LPC-DHA showed a 7-fold improvement in memory tests.

3. APOE4 carriers need longer supplementation

A 2025 study tested LPC omega-3s in APOE3 vs APOE4 mice. APOE3 mice responded within 2 months. APOE4 mice needed 4 months. We need more patience and consistency than the general population.

4. First human trial now underway

The University of Cincinnati launched a trial in February 2025 comparing LPC-DHA vs standard fish oil in 153 adults with mild cognitive decline. Results expected 2026.

Use code: PHOENIX for 20% off to buy Accentrate Omega Max

Stay sharp,

Kevin

P.S. — If you haven't read the original post or watched the video yet, start there. Understanding why LPC-DHA matters will help you decide if it's worth adding to your stack.

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Written by

Phoenix Team

Phoenix Team is a contributor to the APOE4 Blog, sharing evidence-based insights for the APOE4 community.

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