How does APOE4 cause Alzheimer's?
APOE4 does not cause Alzheimer's alone. It raises risk, and research points to five routes: amyloid, tau, immune cells, cholesterol and blood vessels.
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APOE4 does not cause Alzheimer's alone. It raises risk, and research points to five routes: amyloid, tau, immune cells, cholesterol and blood vessels.

A neurologist explains the pattern she looks for, the limits of HRT research, and what she checks beyond symptoms.
DHA, vitamin D, B-vitamins, curcumin: what the research really shows for APOE4 carriers, including where the evidence disagrees.
The MIND diet is tied to a 53% lower Alzheimer's rate. Here's what APOE4 carriers should eat, avoid, and adjust based on the actual research.
The research on doing hard health things alone is brutal. Here's what I built instead

16 studies. 3 clinical trials. The most complete APOE4 + HRT analysis we've ever published.

The JAMA 2026 study is real — but the headlines are wrong. Here's what 2,157 people over 15 years actually showed.

Researchers reversed cognitive deficits in advanced Alzheimer's mice — but issued a stark warning about NMN and NR.

The science changed everything I thought I knew about 'moderate' drinking.
I've been taking LPC-DHA since day one. It's not cheap...but $3/day is nothing compared to the alternative...
We're building an AI that learns what works for you—before you try it.
The uncomfortable truth about cold therapy