The APOE4 Blood Work Panel: What to Test, and When
Originally published on YouTube on 28 January 2026.
Original video: https://www.youtube.com/watch?v=mQMjG1HJ-yo
Free guide: The APOE4 Blood Work Blueprint
https://apoe4.link/Bloodguide
What blood work do I run as an APOE4/4 carrier? I walk through my panel, how I interpret the results, the tests I repeat and the markers discussed in the episode. The original research references and Blood Work Blueprint are included below.
RESOURCES
Apply to join Phoenix: https://apoe4.link/Lbloodpanel
Essential APOE4 Guide: https://apoe4.link/YTbloodpanel
Weekly Newsletter: https://apoe4.link/YTBloodwork
CHAPTERS
00:00 Intro
02:26 Why standard ranges don't apply to ApoE4
03:57 The Inflammation Panel
07:21 The Lipid Panel Upgrade
10:34 Metabolic Health Markers
14:09 Nutrient Status
17:40 Hormone Panel
19:33 Testing Frequency By Age
21:10 The Phoenix Community
ORIGINAL LINKS AND REFERENCES
Tao Q, et al. Association of Chronic Low-grade Inflammation With Risk of Alzheimer Disease in ApoE4 Carriers. JAMA Network Open. 2018. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2707427
Smith AD, et al. Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy. PLoS One. 2010. https://pmc.ncbi.nlm.nih.gov/articles/PMC2935890/
Seshadri S, et al. Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease. NEJM. 2002. https://www.nejm.org/doi/full/10.1056/NEJMoa011613
Jerneren F, et al. Brain atrophy in cognitively impaired elderly: the importance of omega-3 fatty acids and B vitamin status. Am J Clin Nutr. 2015. https://pubmed.ncbi.nlm.nih.gov/25877495/
Zhao N, et al. Apolipoprotein E4 impairs neuronal insulin signaling. Neuron. 2017. https://pmc.ncbi.nlm.nih.gov/articles/PMC5621659/
Sniderman AD, et al. Apolipoprotein B Particles and Cardiovascular Disease. JAMA Cardiol. 2019. https://pmc.ncbi.nlm.nih.gov/articles/PMC7369156/
Ebright B, et al. Effects of APOE4 on omega-3 brain metabolism across the lifespan. Trends Endocrinol Metab. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC11321946/
Chen HY, et al. Ageing related thyroid deficiency increases brain-targeted transport of liver-derived ApoE4-laden exosomes. Cell Death Dis. 2022. https://www.nature.com/articles/s41419-022-04858-x
Saleh RNM, et al. Hormone replacement therapy is associated with improved cognition in at-risk APOE4 women. Alzheimers Res Ther. 2023. https://alzres.biomedcentral.com/articles/10.1186/s13195-022-01121-5