Optimizing Hormones for APOE4 Brain Health: Vitamin D, HRT, Testosterone & Thyroid

Originally published on YouTube on 18 June 2026.
Original video: https://www.youtube.com/watch?v=JEZMcgyEm68

Vitamin D, estrogen, testosterone and thyroid hormones shape how the brain and body age. In this conversation with Dr. Grant Fraser, we discuss what to test, the difference between total and free testosterone, HRT timing and dosing, thyroid symptoms and how to avoid overtesting or overshooting treatment targets.

RESOURCES
Apply to join Phoenix: https://apoe4.link/Hormones
APOE4 Woman's Guide: https://apoe4.link/HormonesG
Weekly Newsletter: https://apoe4.link/HormonesN
APOE4 Blood Work Blueprint: https://apoe4.link/HormonesB

CHAPTERS
00:00 Opening
01:10 Vitamin D, Why the Standard Dose Isn't Enough
03:03 Estrogen & the Critical Timing Window for Brain Protection
07:38 HRT Dosing - Estradiol, Progesterone & What Most Doctors Get Wrong
09:43 Testosterone for Men & Women - Dosing, Targets & What to Expect
15:11 The Number Your Doctor Is Reading Wrong (Free vs Total Testosterone)
17:18 Supraphysiological Testosterone - Why It Ages You Faster
22:03 Physical Signs You Might Have Hypothyroidism
24:14 Closing Advice - How to Test Smart Without Overtesting