How Ezetimibe Took My ApoB Down Nearly 40% (APOE4/4, No Statin)

Originally published on YouTube on 9 June 2026.
Original video: https://www.youtube.com/watch?v=wbDdVGjvdFc

Using diet, psyllium husk and ezetimibe, I lowered my ApoB nearly 40%, from 115 to about 70, without a statin. I walk through my lab panels, the changes I made and the evidence available at the time of this June 2026 recording, including what I was still watching next.

RESOURCES
Apply to join Phoenix: https://apoe4.link/Ezetimibe
APOE4 Lipid Playbook: https://apoe4.link/EzetimibeG
Weekly Newsletter: https://apoe4.link/EzetimibeN
APOE4 Blood Work Blueprint: https://apoe4.link/EzetimibeB

CHAPTERS
00:00 Introduction
03:18 Why APOE4 cholesterol is a different disease
07:29 My actual baseline
09:59 Lever 1: Diet (what I actually eat)
10:50 The Mediterranean pattern
11:35 The 4 moves I made
14:53 Lever 2: Psyllium husk (the underestimated one)
19:41 Lever 3: Ezetimibe (the standout lever, and why I skipped the statin)
28:25 2026 ACC/AHA guideline
29:35 The EZ-PAVE trial
31:05 SWEDEHEART registry results
32:37 The results
35:57 Honest caveats + what I'm watching next
38:58 My lipid blueprint for APOE4 carriers

REFERENCES
Fiber: Jovanovski 2018 PMID30239559; Gibb 2015 PMID26561625; Zhu 2024 PMID38688104; Ghavami 2023 PMID36796439; McRorie 2017 PMID27863994; Schoeneck 2021 PMID33762150; Brum 2018 PMID30078477; Juhász 2023 PMID36811560.

APOE4: Liu 2025 PMID40855194; Husain 2021 PMC7925634; Mahley 2016 PMC4942259; Dunk 2022 PMID34958023; Sniderman 2019 PMC7369156.

Ezetimibe: Nordestgaard 2025 PMID41059729 DOI10.1002/alz.70638; Ganne 2024 PMID39263528; Gorbunova 2024 PMC11927789; Rossi 2025 PMID41400788; Mark 2007 PMID17559752; Pandor 2009 PMID19141093; Ouchi 2019 PMID31434507; Garcia-Calvo 2005 PMID15928087; Cannon 2015 IMPROVE-IT; Awad 2018 PMID29396832; Lee 2021 PMC7935639.

Statins: Rajan 2024 PMID38447103; Westphal Filho 2025 PMC11736423; Banach 2025 PMID40126455.

2026: ACC/AHA Guideline; Ez-PAVE NCT04626973; Leosdottir 2025 PMID40240093.