APOE4: Your Brain Is Insulin Resistant (Even If Your Labs Are Normal)

Originally published on YouTube on 5 April 2026.
Original video: https://www.youtube.com/watch?v=PBL1HS8w58E

Your blood sugar looks fine. Your A1C is normal. But your brain might already be starving for glucose.

I sit down with Dr. Grant Fraser, a board-certified anti-aging and regenerative medicine physician and fellow APOE4 carrier, to explore brain insulin sensitivity, the limits of routine blood tests, diet, ketosis, exercise and treatment options.

RESOURCES
Apply to join Phoenix: https://apoe4.link/Insulin
Essential APOE4 Guide: https://apoe4.link/InsulinG
Weekly Newsletter: https://apoe4.link/InsulinN

CHAPTERS
00:00 Intro
01:05 Trailer
01:48 Introduction & Overview
04:15 Why Brain Insulin Resistance Matters (APOE4)
09:20 Can your labs be perfect but your brain still insulin resistant?
13:44 Which biomarkers to test (and how often)
15:57 The "lazy pancreas" problem nobody talks about
22:35 Fasting glucose vs. fasting insulin: which one actually matters?
26:25 What high insulin + low glucose really means
28:45 Rising HbA1c Despite Being Healthy
34:00 Diet Strategy for Insulin Sensitivity
35:52 What to Do When You Can’t Get Into Ketosis
39:20 Ketone Esters: Are They Worth It?
44:29 CGMs Explained (Dexcom vs Libre 3)
49:46 Fasting When You Go Hypoglycemic
55:06 Exercise: cardio vs. strength for insulin sensitivity
57:16 Metformin vs GLP-1 vs SGLT2 Inhibitors
01:02:12 One Thing to Do This Week