400 APOE4 Patients on Rapamycin. Zero Got Dementia. (Doctor Explains)
Originally published on YouTube on 21 February 2026.
Original video: https://www.youtube.com/watch?v=z7rxmVLAMT0
Free guide: The APOE4 Emerging Therapies Watchlist
https://thephoenix.community/guides/emerging-therapies
In this expert Q&A, Dr. Grant Fraser shares his clinical experience with rapamycin and discusses Dr. Alan Green's APOE4 patient observations. We cover mTOR, dosing and monitoring, cycling, side effects, sleep medications and timing around exercise. This is the February 2026 conversation.
RESOURCES
Apply to join Phoenix: https://apoe4.link/Rapamycin
Essential APOE4 Guide: https://apoe4.link/RapamycinG
Weekly Newsletter: https://apoe4.link/RapamycinN
CHAPTERS
00:00 Introduction
05:03 Understanding Rapamycin: Mechanism and Benefits
10:13 Clinical Experience With APOE4 Carriers
16:13 Monitoring and Adjusting the Dosage
27:59 Addressing Concerns in the Longevity Community
30:30 Right Age To Start
31:54 Dr. Green's Legacy
34:45 Q&A and Conclusion